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Image Search Results
Journal: Cell Reports
Article Title: Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
doi: 10.1016/j.celrep.2022.111124
Figure Lengend Snippet: Complex I deficiency leads to altered mitochondrial function in LHON-affected individuals, which is compensated in carriers (A–D) Measurements of mitochondrial ROS production in LHON-derived 3460 fibroblasts (A) and cybrids (B) and in 11778 fibroblasts (C) and cybrids (D) by using MitoSOX red probe. (E–H) The mitochondrial transmembrane potential (Ψ m ) of 3460 and 11778 fibroblasts and cybrids was detected by using the Ψ m -sensitive probe TMRM. When indicated, the cells were STARV. for 30 min before TMRM loading. Data are presented as means ± SEM. n = at least 5 visual fields per at least 3 independent samples per condition. ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001.
Article Snippet: Total ROS release from mitochondria was estimated fluorometrically by
Techniques: Derivative Assay
Journal: Cell Reports
Article Title: Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
doi: 10.1016/j.celrep.2022.111124
Figure Lengend Snippet:
Article Snippet: Total ROS release from mitochondria was estimated fluorometrically by
Techniques: Recombinant, Enzyme-linked Immunosorbent Assay, Plasmid Preparation, Software